Methylfolate acne reddit. Another odd thing I forgot to mention.

Methylfolate acne reddit How do you determine which to take, especially if you have an MTHFR gene mutation? Supplements that helped MY acne! I just recently was prescribed folic acid (though I requested methylfolate bc MTHFR) and quickly realized it triggers migraines for me. When I hit roughly 18, my acne finally disappeared, and for YEARS up until 6 months ago, I essentially had glass skin. Although in my personal an likely unpopular opinion, many people who had a “bad reaction” to methylfolate have just convinced themselves they did. How methylfolate does this tho is still not yet quite clear. Internet Culture (Viral) L-methylfolate and Quatrefolic. 10 votes, 52 comments. Idk what to do with that info tho lol. My son mostly eats a super healthy diet, so I thought about it a long time, and came to suspect his milk drinking. Eventually I might take folinic acid instead, but it seems like people eventually run into issues there too. The problem went away immediately! People said start up reaction, but for me that was not true. Or check it out in the app stores My last idea is take some extra methylfolate along with the B right to see if i balance out how i feel. I started taking methylpro 10mg about a week ago and i’m starting to get some general low dopamine type symptoms. Unfortunately, I started having a serious rash on the backs of my hands some 20 days into the treatment. . Before I discovered that, I independently discovered that eating cereal fortified with B vitamins helped somewhat, but methylfolate is like a miracle cure. Valheim; Genshin Impact; Minecraft; I like sublingual methylfolate because its fairly easy to break apart a 1000mcg lozenge into pieces as small as 1/8ths for a 125mcg dose. They were saying that for these people, methylfolate was not absorbed as well as folinic acid, and when the kids started taking high doses of folinic acid, all of their severe autism symptoms disappeared! Deplin brand methylfolate (7 mg or 15 mg). Right now I'm taking a smaller dose. I (M29, homozygous C677T) was very worried about taking both methylcobalamin and methylfolate because I heard of increased anxiety and depression being a big part of side effects that people seem to get, every other person on here seems like they were like "yeah I had to quit because this made me feel From my own research this is all I've found---- Does l-methylfolate cause weight gain – As per the above answer, methylfolate can interact with hundreds of biochemical pathways, which means that other biochemical processes may become overwhelmed which can cause weight gain. But I started with a small amount of B12 at a time and titrated my way up to that dose. Ive never had any acne issues i n my life and poof! It suddenly makes an appearance now. Methylfolate is for folate deficiency due to MTHFR gene mutation. I’m about to introduce p5p, as I think I have a masked B6 deficiency. It sucks. Hi! I’ve been taking methyl b12 (500mcg) and methylfolate (400mcg) for the past couple of weeks. r/acne supports a scientific and evidence-based approach to treatment. And I slept like a log last night! So I decided to forgo the methylated multivitamin today as well. Or check it out in the app stores   6 and 12 as well as Nicotinimide and B1 recently and had no negative side effects bar acne from the B12. I took methylfolate as a sublingual and experineced heightened anxiety but now that I take only half of that dose as a normal swallow supplement I don't have side effects anymore. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Anything from Nature Made is reasonably safe. I hate that I have to try to peice all this together rather than have a professional help me, like a doctor, to bad doctors nowadays are nothing but legal drug dealers I've been just experimenting with Methyl B12 and Methylfolate for the past 1. I had to educate my endocrinologist about it, but now he prescribes it for all his MTHFR mutants. Hey guys, So I took 400mcg of Methylfolate and been experiencing some intense anxiety now a few hours after. Sick to my stomach, chills, headache. I started with literally 1/4 of a 1000mcg methylcobalamin sublingual daily and then increased to twice daily then thrice daily, etc. So if you’ve tried both or just tried l-methylfolate for ADD give me your opinions. Upon research I feel like I’m getting conflicting information. From novel/alternative substances, to established medications. Have you checked your zinc and B12 status? Both of these cofactors are necessary in the recycling of methylfolate to folate, and people in this sub will never miss a chance to tell you that folate can mask b12 deficiency lol Zinc deficiency can cause skin lesions, acne, etc as Those 5 straight days were pretty good. As a result, I chose a prenatal that has methylfolate instead of folic acid in it (basically the same nutrient, but partially broken down for easier consumption by my body). Sometimes I also use pimple patches to combat painful inflammations. I have an MTHFR mutation which makes me struggle to process folic acid, so taking methylfolate has pretty much cured all of my skin problems. Users are welcome to share insights and personal experiences with scarring, scar prevention, and treatment options. Heart beating Deplin is used in refractory depression with success. It may increase production of neurotransmitters, while most antidepressants slow the breakdown of neurotransmitters, so they can both result in more A place to discuss skin scarring issues. When I started taking it all I could think about was preventing miscarriage and it didn't even occur to me that it could hurt him after birth. I did get a boost of energy initially but now I believe I'm experiencing those crashing symptoms or overmethylation. Low dose (started at 6mg while taking SSRI): improvement in all symptoms, off SSRI then notices symptoms beginning to return so titrated methylfolate up 1 mg at a time to 15mg/day over ~12 weeks. Seeing slow progress but it's there. Also I kept seeing stuff about how it increases homocysteine even if you take methylfolate and cofactors with it. However, I get acne breakouts with too much B12, even in the short term, so I look to find a sweet spot. g. Methylfolate is the most potent form and can replace BH4 a precursor to neurotransmitters, so it can either fix your mood quickly or send you to a bout of anxiety. You can get 100 1,000 mcg pills for about $12. Or check it out in the app stores     TOPICS. Within 15 minutes, my tingling fingers disappeared. ) So it would take 28mg of methylcobalamin to equal even a single RDA of methylfolate in terms of their stimulation on the methylation pathways. I also do an Omega 3 pill more for heart health than anything but I feel like healthy fats are good for the skin too. Methylfolate isn't a cure and it's a supplement to just make sure my body creates enough of an enzyme to metabolize folate. I’m gonna use it for a few weeks. B12 is 498. I am considering retrying at a much higher dosage (7. And some people for example have issues with acne due to an excretion Get the Reddit app Scan this QR code to download the app now. I decided to add more methylfolate. Then I started feeling more out of it than usual and lethargic. The conversion of folic acid (C19H19N7O6) to l-methylfolate (C20H25N7O6) also requires methyl (click here for image). I just realized that my 3000 mcg B12 everyday suddenly caused me to have breakouts in my chin/jawline area. ADHD is very similar to autism in many ways, so I was interested. I wouldn’t You can use it on acne that's been popped or unpopped so even if you picked at it, it's a great option to use over a moisturizer to shield your acne from environmental Methylfolate makes all of my joints very painful within a day of taking just one tablet and several days to wear off, and methylb12 injections make me feel as though I've been Have you tried folinic acid as an alternative to methylfolate? Start slow Less that 1mg/1000mcg. I can take 20mg of methylfolate or methylb12 now and not experience a thing. 800mcg is a common dosage. For both mild comedonal and mild papulopustular acne, topical retinoids, benzoyl peroxide, and azelaic acid are most often mentioned. Now I realize why. I seem to not be having the severe anxiety on it I once had so I am guessing that my methylation pathways are better and I am more balanced with the SSRI. However after another few hrs that was gone and I started feeling irritable. e. Even tried lowering Methylfolate to 400mcg per day, and it didn't help. Also it is a methyldonor, which might create other issues like reducing dopaminergic neurotransmitters, so buffering it with niacin or glycine seems to be the right choice. I was thinking I should catch up on lost B9. I also get acne if I have whey protein (which is from milk). As taking methylfolate can cause a significant increase in neurotransmitter production, I initially speculated that the first few days were dopamine/norepinephrine heavy, and that serotonin then began causing problems (I tend to respond poorly to increases in serotonin). I have been sleeping extremely poorly, it almost feels like my body is wired and doesn’t need the sleep at night. In a few weeks, I’ll introduce methylfolate. Also try adenosyl hydroxo B12 instead of methylB12. I took about 3/4 of a losenge. How long till i feel like myself again? this is so difficult. I took a prescribed b complex vitamin in addition to my prenatal while I was pregnant and had debilitating migraines 4x as Evening primrose oil 1000 mg worked wonders for my hormonal acne that popped up at 26. Terms & Policies Methylfolate vs Folinic Acid . I stopped Methylfolate on Friday and still experiencing crap symptoms. So apparently this gene mutation and ADD have a link between eachother as I read. My hormonal acne always came back because Accutane does not address the root of the problem. So I had been taking a b complex that had methylfolate in it 400 McG Dr's best fully active b complex. Yesterday, I decided to take the plunge and popped an extra 200mcg of methylfolate after I got home. Thanks. Let's discuss challenges, triumphs, interests, and everything in-between. What would you add to this routine? So far, this has been working. I read somewhere that you must address the low comt first! Methylfolate is just pouring gas over the fire. Riboflavin (FAD) is very important to restore the MTHFR enzyme itself. Hello: how much methyl b12 should i take with 15 mg or more of methyl-folate? Are 5 mg of b12 enough with such a high dose of methylfolate? Thanks 24f, currently dealing with an insanely frustrating and frankly disheartening resurgence of acne out of nowhere. Some of the sublinguals had methylfolate in them too. Folate is 3. I’m hoping to try it for depressive and ADHD type symptoms which i know wellbutrin often helps with. In all reality you could take this prenatal DHA & methylfolate, and beef liver caps and you’d be set in the meantime. Cysts on my temples, cysts on my whole face, cysts cascading down my chin and neck. Was doing ok on it. I was also taking magnesium 400 McG daily, eating potassium rich foods, taking a good multivitamin, fish oil, vitamin c and riboflavin. My hands are still red (probably inflamed), but they don't get dry, itchy, and the skin stopped opening up and bleeding. Pyridoxine HCL is trash. 100% guarentee, if I take a methylfolate lozenge at night, the oily skin and acne is gone the next day. Ever since I took Methylfolate for about a week I developed severe depression all of a sudden and now anxiety is peaking its head in. No misinformation, myths, fearmongering, pseudoscience, DIY/natural/holistic remedies, MLMs, Keto, detoxes, etc. For those struggling with methyl folate dosage, please note that there are many variables at play. I'll stick with LOW dose methylfolate and methylB12 Apparently methylfolate is a good treatment for ADD but most importantly great for people with the MTHFR gene mutation. Has anyone solved this issue? unless you mean methylfolate, which i was not consuming like that but just in methyl-b12 + methylfolate + p5p sublingual tablets that’s interesting that you compare it to wellbutrin. Still can't take methylated b12 though, so I use b12 fortified toothpaste Worth a try Folate fixes the B12 acne for me. Some things get accumulated in fat cells etc, and slowly released. No clindamycin benzoyl peroxide or Tretinoin is helping. View community ranking In the Top 10% of largest communities on Reddit. Can methylfolate lower dopamine . masturbation and acne, opening/closing pores, drinking excess water, using baking soda/lemon juice, claims of microtears, face mapping, discussing supplements, etc. I have changed things every round - added Vitamin B2 (Riboflavin), added NAC, added Vitamin C, Vitamin B1 and the same results every time. It requires a prescription and has to be delivered through the mail, but it often costs half as much as generic methylfolate from a local pharmacy. but the B6 is pyroxidine and the B2 just riboflavin, and it includes 200mcg of calcium l-methylfolate, 100mcg Biotin, 25mg sulfur (for acne and rocasea) azelaic acid (15-20%) tretinoin Madecassoside Reliable -retinol bifida ferment lysate (10% and up for reducing sensitivity and dryness) other typed of acid (lha, pha, mandelic acid,) ceramides (unknow effective concentration) polyglutmic acid (% dunno) laa (l ascorbic acid 5-20%) hey, i’m going through the exact same thing, severe anxiety all day. Still have painful acne flareups but I'm determined to get rid of them through healthy diet and skincare. Unfortunately it has given me cystic acne and horrendous acne scars. BTW in a recent experiment with folinic acid, I experienced the same spike in mental clarity at 2hr mark, no anxiety. Not a place for discussion of illicit and illegal compounds. When I was a teen, I went on two rounds of Accutane, and all through highschool I struggled with acne. You do want to eat a high potassium diet as when you're body is pulling a lot of b12 into your cells it pulls potassium with it I stopped them, took benadryl to reduce excess choline, now I seem to be able to take B2 and even high dose methylfolate (15mg) and they are not causing the same side effects. His acne 90% cleared away. Best to take a genetic blood test I forget what the test is specifically called to look for things like these I am going to keep saying this over and over on this forum because it seriously was a game changer for me. It's too bad that the hype of MTHFR doesn't include info about COMT. The B12 acne started being a daily thing once I tapered up to roughly 3000 mcg in methylcobalamin sublinguals. Mthfr, b12 and acne : r/MTHFR. Overmethylated people who usually tolerate a lot more folate better eat spinach than supplement with l-methylfolate. Get the Reddit app Scan this QR code to download the app now. Talk with a practitioner about the rest of what you need but this is a good starting point to avoid acne and nausea. Be careful with that stuff, take it in low doses. I'm heterozygous for the MTHFR A1298C variant and currently almost 9 months pregnant. I think B2 and methylfolate jack up choline/tmg levels, and if you are high in choline, it makes it go even higher. i started taking l methylfolate on 6/9/23 and stopped on 7/15/23. Methylfolate is also required for serotonin production somehow I have moderately severe acne. My entire pregnancy I have been taking 3-4mg of methylfolate between my prenatal and additional pills. Internet Culture (Viral) Amazing; Animals & Pets I just took methylfolate (L-5-MTHF) as Quatrefolic (6S)-5-methyltetrahydrofolate with B-12 for the first time. For me, it’s recommended that I use hydroxo B12. Has anyone with severe anxiety/depression gotten help from L-Methylfolate? I took 800mcg for a couple of months and at one point went to 3mg a month, but it didn't have an effect. I tried it for like two weeks but ended up stopping cause my fatigue and brain fog came back. Or check it out in the app stores To be safe you might as well take b6, folate (folic acid/methylfolate/folinic acid) and beyond that I don't know. My pdoc recommended a gene test that was free and it turned out both alleles on that gene were mutated for me. However it is incredibly expensive and insurance is not likely to cover it. However, I recently had someone tell me that only folic acid is proven to prevent neural tube defects, and methylfolate has not been shown to have the same effects. Gaming. E. Some people here say to start introducing methylfolate very slowly, like nibbling on a methylated B vitamin a few times per week and slowly, I take 10,000 mcg of methylB12 daily, spread across the day with a bit of methylfolate in each dose. The worst is a severe worsening of restless leg syndrome. It's not as bad, but the acne came back. in most controlled studies using actually drugs, people in the placebo group will drop out due to a “bad reaction” or “intolerable side effects” when in fact they were taking a sugar Get the Reddit app Scan this QR code to download the app now. He had me on 15mg a day and my anxiety increased 5 fold and I started having severe panic attacks thinking it was my Delta-8 THC. An Autistic Community that is centered around women, afabs, nb, queer, trans, and others that are not cis men. Retinoids as a first choice for mostly comedonal acne BP as a first choice for mostly papulopustular acne Anecdotally, BHAs can be useful for open comedones (blackheads). This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. You most likely have COMT mutations in addition to your MTHFR mutations. That said, you could try folinic acid as it's an "active Okay, so a question for all you mthrf:ers out there (possibly more than one). You can get L-methylfolate in calcium salt (most bioavailable) from Methyl Pro at a high does for reasonable cost. Also noticed Methylfolate on its own without Methyl-B12 doesn't do anything positive for me. I tried Carlyle opti-folate and it doesn't work for me. It is strongly encouraged to see an experienced, board-certified dermatologist for proper guidance I have tried Methylfolate and Methyl B12 and always had pretty significant issues with them (overmethylation symptoms basically pretty extreme anxiety whatever else comes along with it) I've also noticed the same from other things that seem to ramp up methylation Get the Reddit app Scan this QR code to download the app now. I seemed to have plateaued in my recovery. But thats honestly how it should be. 400 mcg methylfolate 500 mcg methylcobalamin I used to take 1,600 mcg methylfolate but found 400 mcg is just as effective. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Most of the time, I think people don't realize it can be caused by diet. Another odd thing I forgot to mention. I've never had this kind of acne problem before I started taking folic acid. This supplement contain other things like methylcobalamine (that causes acne) and alpha-lipoic acid (very well tolerated but can cause dizziness, headache and weakness in some people). Instead I take: B12: adensocobalamin or hydroxycobalamin Folate: Folinic acid (calcium folinate). So, it makes more sense to add folate for overmethylated people that convert to l-methylfolate. I was recommended to start taking 15mg of l-methylfolate a day. It seems it could, as well with serotonin and norepinephrine as SAM-e is required for the synthesis of all of those, and that would get used up pretty quickly for the synthesis of methylfolate or methyl b12. Here is the bottle info: Get the Reddit app Scan this QR code to download the app now. I have other confounding factors like dysfunctional childhood and cocaine addiction but I believe MTHFR is the primary reason I had ADHD. I would have never correlated it with Vitamin B12 usage till I saw this A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. If I'm not cramming fist fully of b vitamins every day down my thought then I get body acne and my hunger drive goes way up. Lowering the dose as low as 25mcg for methylfolate is sometimes needed to curb the side effects, and you can slowly add 25mcg a day from Get the Reddit app Scan this QR code to download the app now. The backs of my hands were dry and cracks started appearing in them, oozing blood. I had him give it up for 6 weeks. However due to anxiety and insomnia from Methylfolate, I've decided to stop it now, for at least a few weeks (maybe months), then start with very Does elevated homocysteine cause any noticeable symptoms? (Besides an extreme/acute event like a stroke or heart attack?) I’m looking back on a time before I started on methylfolate and wondering whether I could have had elevated homocysteine then; I’ve never had it tested and my doctors aren’t concerned bc I only have one copy of C677Tbut I had been taking a bunch of For me it was acne. Here is the bottle info: But we are all different. I’ll link two of those that I really love from both a quality standpoint AND an acne safe (for me) standpoint: I was taking Thorne 15mg l-methylfolate, but it's been discontinued and I don't know what to do. Since 2020, I’ve done many treatments to treat/control/manage acne and acne scarring. My teenage son has some acne. My psychiatrist prescribed me L-methylfolate to help my anti depression meds do their job. But you should take N-acetyl cysteine (NAC) I went on Accutane three times between ages 16-28. How long until this crap goes away? I feel depressed until evening then it eases up until the next morning. I worked with professionals to heal my gut and balance my hormones to the best of my ability. Yes, you need to take methylfolate. Folate sufficiency is important And I would take a high dose of a good b complex with 100 mg of all the b vitamins (except b6 and folate), at least 400 mcg methylfolate (add more methylfolate if needed) and 10-25 mg P5P. On this day--with no injection--I took in 3200mcg methylfolate and 4100mcg B12 (methyl and adeno, but not injected). Today I tried a B The best thing you can do is cut out gluten and casein to reduce the FRAA’s and then you will be able to start taking methylfolate. COMT mutations are the ones that make you mentally ill (together with MAO) because of the slow (COMT) reuptake of neurotransmitters. Symptoms would resolve upon increased dose and then slowly return over a couple weeks until I increased dose. She reccomended I take methylpholate and avoid folic acid entirely as with my mutations it can lead to a build up of homocystine which is associated with higher rates of stroke and also miscarriages. 2. Again, Liquid methylfolate or folinic acid are good choices in my opinion. B12 completely ruined my skin! I used to have the most clear skin with no scars but since February my face has not been the same. Also at least 300-600 mg Methylfolate helped me feel better, which was quite a surprise. Try a formulation that Worth a shot but it’s not completely straightforward for everyone that the methylfolate will help them more and can actually cause anxiety but for others it can relieve it. I got genetic testing done, found out I have a folate deficiency and an inability to process folic acid, began supplementing with methyl folate, and my symptoms are like 80% better on a daily basis and my only side effect is a little acne on my back when I take too much folate yes accutane is the best solution to acne and it completely got rid of it for me, but after you stop taking accutane your skin IS still prone to getting acne and you still have to be cautious, so don’t take my advice for granted just because i’ve used accutane, i still got reaaaalllyy bad acne after and learnt all the tips i’m about to Get the Reddit app Scan this QR code to download the app now. I stopped the L-methylfolate and the condition resolved. Found out I can’t take too many methylated supplements - vitamins in the form with a methyl in front (methylcobalamin / methylfolate). I currently take 1,000 mcg of methylfolate a day since I had a mini-stroke 8 years ago and they told me in the hospital folate was a good supplement for preventing future strokes. I was so relieved when I found out it was the Methylfolate. Valheim; Genshin Impact However, I decided to try 1000mcg sublingual methylfolate and I felt horrendous. I started taking them December/January and stopped in February when I realized how bad my face was getting. Is there any benefit of one form over the other or they are essentially the same? Quatrefolic is glucosamine salt of (6S)-5-methyltetrahydrofolate Share I personally take magnesium glycinate, and have added methylated B12 and l-methylfolate (calcium salt form) to that, which has helped to stop the persistent headaches that I was experiencing. Currently I'm having success with the basics, taking methylfolate/b12 and nothing else other than vitamin d. Even after making progress on those fronts, the acne remained. Symptoms were minimal! On the 6th day, I had to fly out of town and just took sublinguals and liquid b12. Valheim; Genshin Impact I'm homozygous C677T. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. 5 mg), but I want to make sure this is worth my time since anxiety and depression sucks. 5 weeks due to suspected B12 deficiency symptoms and I think they may have caused more harm than good. Highly recommend trying a good quality vitamin E. For context, I’ve been taking beta blockers to reduce some persistent hypertension that doesn’t respond to diet or exercise. Lots of anecdotes of people who didn't fully recover until they added methylfolate to their B12 regimen, but also a lot of posts like yours where people see old deficiency symptoms flare up or get worse after adding in folate. “It’s just a supplement, surely it won’t have any side effects/etc” WRONG lol Shortly after taking it I felt TERRIBLE. Hey guys! I come It also got rid of all of my period cramps, no more cystic acne, stopped me from getting sunburned as easily, and got rid of my food aversions. I got super dizzy by So 10mcg of a substance with methyl groups, as opposed to a standard methylfolate dose of 400mcg at ~70% absorption (280mcg of a substance w/ methyl groups. I found that too many processes rely on folate and it’s hard to control it’s usage for the one thing you care about. Stopped taking it for a month and my skin cleared up. I've been wondering why I suddenly had these bumps on my forehead that would never go away. Hey I have these mutations too, my physician reads a lot of literature about it as she also has mutations for both mthfr genes. First day or two felt OK. It is 7/17/23 as of writing this. Honestly the need for folate seems to be highly individual. Yes, the methylfolate has kept working consistently for my atopic dermatitis. Barely anything vs the Thorne helping with my energy levels. Methylfolate is basically something your body should make anyway. Heard about methyl folate and decided to try it out since it wasn’t I am not diagnosed with the MTHFR mutation but my Folate levels are low, basically right on the range of normal in the UK. Statements made on this subreddit should not be considered as a substitute for advice from a healthcare professional. "Natural" and "clean" Methylfolate used to make me severely anxious but my physician said to stay with it as I am eventually trying for a baby and it’s the most important supplement for someone like me. mbipndm nhj gujdqc pgiv gzwzbkg eqcu zwz jde lji xnuw bnvkwp zkdnrjr tfbgo hhi oxcq